| Orale House #F7 | 1979 W 25th ST | 24-Jan-2024 |
| Orca House | 3001 Prospect AVE | |
| Orchard Park Academy | 14440 Triskett Rd | 17-Apr-2023 |
| Orchard School | 4200 Bailey Ave | 13-Dec-2023 |
| Oriana | 1829 E 55th Street | 14-Dec-2023 |
| Oriana House | 1829 E 55th Street | 26-Dec-2023 |
| Orianna House | 3540 Croton Ave | 14-Dec-2023 |
| Original Dante's Pizza | 4176 Rocky River Drive | 16-Feb-2024 |
| Original Grill | 17406 St Clair Avenue | 15-Apr-2024 |
| Orlando Bakery/Cuyahoga Group | 7777 Grand AVE | 4-Apr-2024 |
| Osteria Italian | 1801 E 9th ST | 24-Jan-2024 |
| Otani Noodle | 11472 Euclid AVE | 17-Oct-2023 |
| Otani Noodle Downtown, Inc. | 234 Euclid Ave | 24-Apr-2024 |
| Our Community Childcare Center | 9250 Miles Park AVE | |
| Our Lady of Angels | 3644 Rocky River Drive | 8-Dec-2023 |
| Our Lady of Mt Carmel Cafeteria | 1355 W 70th Street | 9-Apr-2024 |
| Oven Fresh Pizza | 7146 Denison | 21-Feb-2024 |
| Oven Fresh Pizza Co. | 7001 Harvard | 29-Jan-2024 |
